https://ogma.newcastle.edu.au/vital/access/ /manager/Index ${session.getAttribute("locale")} 5 https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:51358 Wed 28 Feb 2024 16:08:47 AEDT ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:42460 FTO) single-nucleotide polymorphism (SNP) rs9939609 is a major SNP associated with obesity and has been used as an instrumental variable for obesity in a Mendelian randomization (MR) approach. An interaction between the FTO SNP and macronutrient intake for obesity was suggested previously. Objective: The aim of this study was to assess the associations between obesity and cataract, using FTO SNP rs9939609 as an instrumental variable in an MR approach, and explore interactions of this SNP with macronutrient intake in relation to risk of cataract in a population-based cohort. Methods: The Blue Mountains Eye Study (BMES) is a longitudinal population-based study of common eye disease. Of 3654 baseline participants of the BMES (1992-1994), 2334 (75.8% of survivors) and 1952 (76.7% of survivors) were followed 5 and 10 y later. During the 5-y follow-up, 1174 new participants were examined. Cumulative cataract was defined as the presence of cortical, nuclear, or posterior subcapsular (PSC) cataract at any visit, following the Wisconsin Cataract Grading System. Imputed dosage of the FTO SNP rs9939609 was used. Quintiles of macronutrient intake (carbohydrates, protein, fats) were derived from an FFQ. ORs and 95% CIs were estimated using multivariable-adjusted logistic regression models. Results: After multivariable adjustment, there were no associations between BMI and any cataract types in MR models using rs9939609 as an instrumental variable. However, an interaction between rs9939609 and protein intake for PSC cataract risk was suggested (P = 0.03). In analyses stratified by quintiles of protein intake, each minor allele of rs9939609 was associated with increased odds of PSC (OR: 2.14; 95% CI: 1.27, 3.60) in the lowest quintile subgroup only. Conclusions: Obesity was not causally associated with age-related cataract. However, among persons in the lowest quintile of protein intake, obesity may be associated with PSC cataract.]]> Wed 24 Aug 2022 11:18:26 AEST ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:41663 Wed 13 Mar 2024 18:26:17 AEDT ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:29933 15 µmol/L: OR = 2.24; 95% CI = 1.38-3.63) were independently associated with increased risk of cortical cataract. Path analysis showed that the genetic effect on cortical cataract was partially mediated via homocysteine levels. Combined CT/TT genotypes and elevated homocysteine levels were associated with a 3-fold risk of cortical cataract (OR = 3.74; 95% CI = 1.79-7.80). The synergy index of both exposures was 1.34 (95% CI = 0.44-4.01). Conclusions and Relevance: MTHFR polymorphism and elevated homocysteine levels contributed separately and jointly to increased risk of cortical cataract. If these findings are confirmed, homocysteine levels may be a therapeutic target to reduce risk of cortical cataract in persons carrying genetic risk.]]> Wed 10 Nov 2021 15:04:55 AEDT ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:48776 Wed 05 Apr 2023 14:02:56 AEST ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:36667 2 standard alcoholic drinks/day (41.2%). In conclusion, large fractions of kidney and bladder cancers in Australia are preventable by behavior change.]]> Tue 26 Jul 2022 11:43:54 AEST ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:37400 n = 214,536) to national cancer and death registries, and estimated the strength of the associations between behaviours causally related to cancer incidence and death using adjusted proportional hazards models. We estimated exposure prevalence from representative health surveys. We combined these estimates to calculate Population Attributable Fractions (PAFs) with 95% confidence intervals (CIs), and compared PAFs for population subgroups. During the first 10 years follow‐up, there were 640 incident breast cancers for premenopausal women, 2,632 for postmenopausal women, and 8,761 deaths from any cause. Of future breast cancers for premenopausal women, any regular alcohol consumption explains 12.6% (CI = 4.3–20.2%), current use of oral contraceptives for ≥5 years 7.1% (CI = 0.3–13.5%), and these factors combined 18.8% (CI = 9.1–27.4%). Of future breast cancers for postmenopausal women, overweight or obesity (BMI ≥25 kg/m2) explains 12.8% (CI = 7.8–17.5%), current use of menopausal hormone therapy (MHT) 6.9% (CI = 4.8–8.9%), any regular alcohol consumption 6.6% (CI = 1.5–11.4%), and these factors combined 24.2% (CI = 17.6–30.3%). The MHT‐related postmenopausal breast cancer burden varied by body fatness, alcohol consumption and socio‐economic status, the body fatness‐related postmenopausal breast cancer burden by alcohol consumption and educational attainment, and the alcohol‐related postmenopausal breast cancer burden by breast feeding history. Our results provide evidence to support targeted and population‐level cancer control activities.]]> Tue 25 Oct 2022 09:19:19 AEDT ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:47647 P = 0.007) and for those under 65 (19.0%; 95% CI, 8.1–28.6%) than for older people (6.6%; 95% CI, 1.9–11.1%; P = 0.030). There were no independent relationships between body mass index or alcohol consumption and pancreatic cancer. Conclusions: Strategies that reduce the uptake of smoking and encourage current smokers to quit could substantially reduce the future incidence of pancreatic cancer in Australia, particularly among men.]]> Tue 24 Jan 2023 14:51:37 AEDT ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:35110 Pdifference < .001). The burden attributed to these factors was also higher for those born in Australia (28.7%) than elsewhere (16.8%, Pdifference = .047). We observed modification of the smoking-attributable burden by alcohol consumption and educational attainment, and modification of the obesity-attributable burden by age group and birthplace. Conclusions: We produced up-to-date estimates of the future CRC burden attributed to modifiable behaviors. We revealed novel differences between men and women, and other high–CRC burden subgroups that could potentially benefit most from programs that support behavioral change and early detection.]]> Thu 24 Mar 2022 11:32:50 AEDT ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:30583 Thu 17 Mar 2022 14:38:56 AEDT ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:11338 Sat 24 Mar 2018 08:13:29 AEDT ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:21760 Sat 24 Mar 2018 07:53:07 AEDT ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:25737 Clinical practice guidelines and principles of care for people with dementia (Guidelines) was recently approved by the National Health and Medical Research Council (NHMRC). Objective: This article describes the recommendations within the Guidelines that are of greatest relevance to GPs, including those addressing diagnosis, living well, managing behavioural and psychological symptoms, supporting carers, and the palliative approach. Discussion: The Guidelines synthesise current evidence in dementia care and emphasise: timely diagnosis; encouraging the person with dementia to exercise, eat well and keep doing as much for themselves as possible; supporting and training carers to provide care; and reducing prescription of potentially harmful medications where possible.]]> Sat 24 Mar 2018 07:30:43 AEDT ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:43046 6.0 mM (strata-specific OR 1.72, 95% CI 1.09–2.72). No similar association was found in participants with normal FBG (OR 0.85, 95% CI 0.69–1.04). This interaction was not evident in the SEED study. Conclusions: The identified interaction between rs9640883 and FBG in relation to cortical cataract was not replicated but may warrant further investigation.]]> Mon 12 Sep 2022 12:59:35 AEST ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:35870 Fri 21 Oct 2022 11:25:56 AEDT ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:45747 Fri 04 Nov 2022 10:26:56 AEDT ]]>